TOPIC
Nanotechnology in the diagnosis of bacterial infection: current trends, challenges and future prospects

AUTHORS

Salaudeen Abdulafeez Ololade, Ojo Josephine Folasade, Lawal Olukayode Adeayo, Imohimi-Oduru Richard Mofedamijo, Ibrahim Ayisat Abiola, Emmanuel Ifeanyi Obeagu and Abdulwasiu Oladele Hassan


ABSTRACT
By delivering quick, sensitive, and targeted detection methods that have dramatically
improved the diagnosis and treatment of bacterial illnesses, nanotechnology has
revolutionized the field of bacterial diagnosis. This abstract seeks to provide a concise
overview of the present trends, difficulties, and potential applications of nanotechnology in
bacterial detection. The creation of nanoparticles that can find bacteria at incredibly low
concentrations is one of the most recent developments in bacterial diagnosis. Nanoparticles
can detect bacteria with great sensitivity and selectivity by utilizing the unique surface
characteristics of bacterial cells and their interactions with different nanomaterials. These
nanosensors offer significant promise for point-of-care diagnostics since they can
successfully identify bacteria in clinical samples like urine blood and saliva. However,
bacterial diagnostics based on nanotechnology also faces substantial obstacles. The absence
of regulatory standards and guidelines for nanosensors is a significant problem. In order to
verify the safety and effectiveness of these devices for clinical application, regulatory
guidelines are required because the lack of standardization makes it impossible to compare
the results acquired from various nanosensor platforms. Further research is necessary since
the possible toxicity of the nanomaterials utilized in nanosensors is a serious concern.
Despite these difficulties, nanotechnology has bright future potential for bacterial
diagnostics. The creation of nanotherapeutics that can specifically target and kill bacterial
cells without endangering host cells is one possible application. In addition to providing an
alternate method of treating bacterial illnesses, these nanotherapeutics can break the
bacterial resistance to antibiotics. Additionally, the creation of cutting-edge nanosensors and
imaging methods can advance our comprehension of bacterial pathogenesis and aid in realtime monitoring of treatment efficacy. In conclusion, nanotechnology has had a substantial
impact on bacterial diagnosis and has enormous potential to enhance both bacterial infection
detection and therapy. The difficulties of bacterial diagnosis using nanotechnology must be
overcome, and further study is required to create and improve nanosensors,
nanobiotechnology chips and nanotherapeutics for clinical usage.
Keywords: Nanotechnology, diagnosis, bacterial infection, current trends, challenges, future
prospects


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PUBLISHED

2023-05-03

HOW TO CITE

Salaudeen Abdulafeez Ololade, Ojo Josephine Folasade, Lawal Olukayode Adeayo, Imohimi-Oduru Richard Mofedamijo, Ibrahim Ayisat Abiola, Emmanuel Ifeanyi Obeagu and Abdulwasiu Oladele Hassan (2023). Nanotechnology in the diagnosis of bacterial infection: current trends, challenges and future prospects. IDOSR Journal of Applied Sciences 8(2) 108-121, 2023. https://doi.org/10.59298/IDOSR/2023/10.1.7008