Integrative Perspectives on Antioxidant-Mediated Neuromodulation and Hepatoprotection: Natural Product Strategies Against Metabolic and Environmental Insults
Mukamana Sandra Gisele
School of Applied Health Sciences Kampala International University Uganda
ABSTRACT
The liver and brain are interconnected through a complex network known as the liver-brain axis, which plays a pivotal role in maintaining systemic homeostasis. Disruptions in this communication, due to environmental toxins or metabolic disorders, can lead to a range of health issues affecting both organs. Antioxidants, particularly those derived from natural products, have garnered attention for their potential to modulate oxidative stress, inflammation, and metabolic dysfunctions associated with these conditions. This review explores the mechanisms by which natural antioxidants exert protective effects on both the liver and brain, highlighting their role in mitigating the impact of environmental and metabolic insults. Emphasis is placed on the activation of key molecular pathways, such as the Nrf2/ARE signaling pathway, which governs the expression of antioxidant enzymes and cellular defense mechanisms. Additionally, the review discusses the therapeutic potential of various natural compounds, including polyphenols, flavonoids, and carotenoids, in restoring balance to the liver-brain axis. The synergistic effects of these compounds, when combined with lifestyle interventions like diet and exercise, are also examined. Understanding the integrative actions of natural antioxidants offers promising avenues for developing holistic therapeutic strategies aimed at preserving liver and brain health in the face of environmental and metabolic challenges.
Keywords: Antioxidants, Neuromodulation, Hepatoprotection, Natural Products, Metabolic Disorders
CITE AS: Mukamana Sandra Gisele (2026). Integrative Perspectives on Antioxidant-Mediated Neuromodulation and Hepatoprotection: Natural Product Strategies Against Metabolic and Environmental Insults. IDOSR JOURNAL OF BIOLOGY, CHEMISTRY AND PHARMACY 11(1):62-66. https://doi.org/10.59298/IDOSR/JBCP/26/102.6266