Plant-Based Compounds in the Management of Metabolic Syndrome: A Review

Abner Tom Kalukusu

Department of Clinical Medicine and Dentistry Kampala International University Uganda

Email: abnertomkalukusu@studwc.kiu.ac.ug

ABSTRACT

Metabolic syndrome (MetS) is a group of interrelated risk factors, including central obesity, insulin resistance, dyslipidemia, and hypertension that increase the risk of developing cardiovascular diseases, type 2 diabetes, and other chronic conditions. The global prevalence of MetS has been steadily rising, largely driven by sedentary lifestyles and poor dietary habits. While conventional pharmacological treatments are essential for managing MetS, there is growing interest in plant-based compounds as potential therapeutic agents. These compounds offer promising benefits due to their ability to address multiple aspects of MetS, including inflammation, oxidative stress, insulin resistance, and lipid metabolism, with minimal side effects. This review provides an overview of several plant-based compounds, such as curcumin, resveratrol, berberine, green tea catechins, and cinnamon, highlighting their mechanisms of action, clinical evidence supporting their use, and potential for future treatment options. By exploring the efficacy of these natural compounds, this review aims to contribute to the understanding of alternative and complementary approaches in managing MetS, with a focus on their therapeutic potential, safety, and clinical applicability.

Keywords: Metabolic syndrome, Plant-based compounds, Insulin resistance, Inflammation, Therapeutic agents

CITE AS: Abner Tom Kalukusu (2025). Plant-Based Compounds in the Management of Metabolic Syndrome: A Review. IDOSR JOURNAL OF BIOLOGY, CHEMISTRY AND PHARMACY 10(1):24-29. https://doi.org/10.59298/IDOSR/JBCP/25/101.242900