Dietary Phytochemicals and their Impact on Androgen Disorders in Males

Nagawa Jackline Irene

Department of Clinical Medicine and Dentistry Kampala International University Uganda

Email: irene.nagawa@studwc.kiu.ac.ug

ABSTRACT

Androgen disorders in males, including conditions such as hypogonadism, androgen deficiency, and androgenic alopecia, result from hormonal imbalances that can significantly impact reproductive health, metabolism, and overall well-being. Emerging research highlights the potential role of dietary phytochemicals, naturally occurring bioactive compounds found in plants, in modulating androgen levels and mitigating the effects of these disorders. Various classes of phytochemicals, including flavonoids, lignans, polyphenols, and alkaloids, exhibit mechanisms of action that influence androgen metabolism, receptor activity, and overall endocrine function. These compounds exert their effects through modulation of enzymatic pathways, inhibition of androgen receptor signaling, and antioxidative and anti-inflammatory properties that support hormonal balance. Understanding the impact of dietary phytochemicals on androgen disorders may provide new therapeutic avenues and dietary interventions to enhance male hormonal health. This review aims to explore the current scientific evidence on phytochemicals and their potential applications in the management of androgen-related conditions, highlighting their mechanisms, clinical relevance, and future research directions.

Keywords: Androgen disorders, Phytochemicals, Hormonal balance, Androgen metabolism, Dietary interventions

CITE AS: Nagawa Jackline Irene (2025). Dietary Phytochemicals and their Impact on Androgen Disorders in Males. IDOSR JOURNAL OF BIOLOGY, CHEMISTRY AND PHARMACY 10(1):36-41. https://doi.org/10.59298/IDOSR/JBCP/25/101.364100