Diabetes and Obesity: Mechanistic Insights

Wambui Kibibi J.

 

School of Natural and Applied Sciences Kampala International University Uganda

ABSTRACT

Obesity and type 2 diabetes (T2D) are interrelated global health challenges with rising prevalence and profound socioeconomic impact. Central adiposity is a key driver of metabolic dysfunction, contributing to insulin resistance, β-cell stress, and dysregulated energy homeostasis. Adipose tissue functions as an active endocrine organ, secreting adipokines, lipokines, and inflammatory mediators that influence systemic metabolism and promote T2D development. Mechanistic pathways linking obesity to T2D include chronic inflammation, ectopic fat deposition, lipotoxicity, mitochondrial dysfunction, gut microbiome alterations, and dysregulated neural and hormonal control of appetite and glucose homeostasis. Genetic, epigenetic, and developmental factors further modulate individual susceptibility. Understanding these complex interactions provides a basis for translational interventions targeting metabolic pathways, adipose tissue function, and energy balance to prevent or delay T2D onset. Future research should focus on identifying precise biomarkers, elucidating multi-organ crosstalk, and developing interventions that mitigate metabolic dysfunction independent of weight loss.

Keywords: Obesity, Type 2 diabetes, Insulin resistance, Adipokines and Metabolic dysregulation.

CITE AS: Wambui Kibibi J. (2026). Diabetes and Obesity: Mechanistic Insights. IDOSR JOURNAL OF APPLIED SCIENCES 11(1):83-88. https://doi.org/10.59298/IDOSRJAS/2026/1118388